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KMID : 0352419950140020187
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Keimyung Medical Journal
1995 Volume.14 No. 2 p.187 ~ p.191
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Surgical Treatment of Patients with Intractable Epilepsy Associated with Cortical Dysplasia
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Abstract
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The advent of neuroimaging technique has enabled the accurate diagnosis of structural abnormalities associated with intractable epilepsy. Among these, neuronal migration disorders(NMDs) or cortical dysplasias(CDs) involving cerebral cortex are
increasingly recognized as a mojor cause of intractable epilepsy. CDs are expressed as variety of forms depending upon the time of injury to the developing nervous system. CDs are highly and intrinsically epileptogenia. It is crucial to
completely
resect the epileptogenic zone in focal CDs for better seizure outcome. Hemispherectomy or multilobar resection is preferred for hemimegalencephaly. Callosotomy can be chosen in the diffuse CDs who have intractable drop attacks. However, resective
surgery can benefit the selected patients with diffuse CDs if localizing information persists
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